Anticancer Activity of Diosgenin and Its Molecular Mechanism.
10.1007/s11655-023-3693-1
- Author:
Qun-Li REN
1
;
Qian WANG
1
;
Xin-Qun ZHANG
2
;
Miao WANG
1
;
Huan HU
1
;
Jun-Jie TANG
3
;
Xiong-Tong YANG
3
;
Ying-Hui RAN
3
;
Huan-Huan LIU
3
;
Zhi-Xing SONG
3
;
Jian-Guo LIU
4
;
Xiao-Lan LI
5
Author Information
1. Special Key Laboratory of Microbial Resources and Drug Development, Higher Education Institution, Zunyi, Guizhou Province, 563000, China.
2. Zheng'an County people's Hospital, Zunyi, Guizhou Province, 563000, China.
3. School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
4. School of Stomatology, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
5. Special Key Laboratory of Microbial Resources and Drug Development, Higher Education Institution, Zunyi, Guizhou Province, 563000, China. lixiaolanl@163.com.
- Publication Type:Review
- Keywords:
anticancer;
biological activity;
diosgenin;
molecular mechanism;
steroidal sapogenin
- MeSH:
Male;
Humans;
Carcinoma, Squamous Cell/drug therapy*;
Diosgenin/metabolism*;
Mouth Neoplasms/drug therapy*;
Apoptosis;
Prostatic Neoplasms/drug therapy*
- From:
Chinese journal of integrative medicine
2023;29(8):738-749
- CountryChina
- Language:English
-
Abstract:
Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea, and Rhizoma polgonati, has shown high potential and interest in the treatment of various cancers such as oral squamous cell carcinoma, laryngeal cancer, esophageal cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, prostate cancer, glioma, and leukemia. This article aims to provide an overview of the in vivo, in vitro, and clinical studies reporting the diosgenin's anticancer effects. Preclinical studies have shown promising effects of diosgenin on inhibiting tumor cell proliferation and growth, promoting apoptosis, inducing differentiation and autophagy, inhibiting tumor cell metastasis and invasion, blocking cell cycle, regulating immunity and improving gut microbiome. Clinical investigations have revealed clinical dosage and safety property of diosgenin. Furthermore, in order to improve the biological activity and bioavailability of diosgenin, this review focuses on the development of diosgenin nano drug carriers, combined drugs and the diosgenin derivatives. However, further designed trials are needed to unravel the diosgenin's deficiencies in clinical application.
