Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis.
10.1007/s11655-022-3531-x
- Author:
Han LI
1
;
Xiao-Feng YE
1
;
Yang-Shuai SU
2
;
Wei HE
2
;
Jian-Bin ZHANG
3
;
Qi ZHANG
1
;
Li-Bin ZHAN
3
;
Xiang-Hong JING
4
Author Information
1. Department of Acupuncture and Moxibustion, Changzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu Province, 213002, China.
2. Research Center of Meridians, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
3. Nanjing University of Chinese Medicine, Nanjing, 210023, China.
4. Research Center of Meridians, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China. jxhtjb@263.net.
- Publication Type:Review
- Keywords:
acupuncture and moxibustion;
gut microbiota;
intestinal epithelial cells regeneration and death;
mucosal healing;
tight junction function;
ulcerative colitis
- MeSH:
Rats;
Animals;
Colitis, Ulcerative/metabolism*;
Moxibustion;
Rats, Sprague-Dawley;
Acupuncture Therapy;
Acupuncture
- From:
Chinese journal of integrative medicine
2023;29(9):847-856
- CountryChina
- Language:English
-
Abstract:
The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall (mechanical barrier) injury with the imbalance between intestinal epithelial cells (IECs) regeneration and death, as well as tight junction (TJ) dysfunction. It is suggested that biological barrier (gut microbiota), chemical barrier (mucus protein layer, MUC) and immune barrier (immune cells) all take part in the imbalance, leading to mechanical barrier injury. Lots of experimental studies reported that acupuncture and moxibustion on UC recovery by adjusting the gut microbiota, MUC and immune cells on multiple targets and pathways, which contributes to the balance of IEC regeneration and death, as well as TJ structure recovery in animals. Moreover, the validity and superiority of acupuncture and moxibustion were also demonstrated in clinic. This study aims to review the achievements of acupuncture and moxibustion on mucosal healing and analyse the underlying mechanisms.
