Progress of BRAF Gene Alteration in Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2024.101.01
- VernacularTitle:BRAF突变在非小细胞肺癌中的研究进展
- Author:
DENG LIBIAN
1
;
YANG YAXIAN
;
HUANG JIAN
Author Information
1. 524002 湛江,广东医科大学附属第二医院病理科
- Keywords:
Lung neoplasms;
BRAF gene;
Targeted therapy
- From:
Chinese Journal of Lung Cancer
2024;27(1):73-80
- CountryChina
- Language:Chinese
-
Abstract:
V-Raf murine sarcoma viral oncogene homolog B(BRAF)alteration is one of the most essential driver genes of non-small cell lung cancer(NSCLC).BRAF encodes serine/threonine protein kinases,and its mutations typically lead to protein compositional activation,thereby activating the mitogen-activated protein kinase kinase(MEK)signaling pathway.A promising new approach for the treatment of mutated BRAF and/or downstream MEK may provide customized treatment op-portunities for BRAF driven NSCLC patients.However,combination therapy is necessary to overcome the difficulties such as short duration of benefit,poor therapeutic effect of non-V600 BRAF mutations and susceptibility to drug resistance.This article reviewed the progress in structural characteristics,related signaling pathways,mutation types of BRAF gene,and the clinical pathological relationship between BRAF mutations and NSCLC,as well as the therapy,in order to provide more evidences for clinical doctors to make treatment decisions.
