Research Progress of Granulocytic Myeloid-derived Suppressor Cells in Non-small Cell Lung Cancer

VernacularTitle:粒细胞样髓源性抑制细胞在非小细胞肺癌中的研究进展
Author: YANG CHAODAN ^{1
,

2
,

3} ; ZHU RUI ; ZHANG YUTING ; YING LISHA ; WANG JIAMIN ; LIU PAN ; SU DAN
Author Information

1. 310024 杭州,国科大杭州高等研究院分子医学院
2. 201203 上海,中国科学院上海药物研究所
3. 100049 北京,中国科学院大学
Keywords: Lung neoplasms; Granulocytic myeloid-derived suppressor cells; Immune microenvironment; Immunotherapy; Targeted therapy
From: Chinese Journal of Lung Cancer 2024;27(1):65-72
CountryChina
Language:Chinese
Abstract: Granulocytic myeloid-derived suppressor cells(G-MDSCs)are one of the main subgroups of MD-SCs,which are widely enriched in most cancers.It can inhibit the killing function of T-lymphocyte through the expression of arginase-1(Arg-1)and reactive oxygen species(ROS),reshape the tumor immune microenvironment,and promote the oc-currence and development of tumors.In recent years,more and more studies have found that G-MDSCs are significantly cor-related with the prognosis and immunotherapy efficacy of patients with non-small cell lung cancer,and the use of drugs specifi-cally targeting the recruitment,differentiation and function of G-MDSCs can effectively inhibit tumor progression.This article reviews the immunosuppressive effect of G-MDSCs in non-small cell lung cancer and the progress of related pathway targeting drugs.