Hypothesis of Genetic Diversity Selection in the Occurrence and Development of
Lung Cancer: Molecular Evolution and Clinical Significance.
10.3779/j.issn.1009-3419.2023.101.34
- VernacularTitle:肺癌发生发展的遗传多样性选择假说
- Author:
Baodong LIU
1
Author Information
1. Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
- Publication Type:Journal Article
- Keywords:
Clinical significance;
Genetic diversity;
Lung neoplasms;
Molecular evolution;
Selection
- MeSH:
Humans;
Lung Neoplasms/genetics*;
Clinical Relevance;
Evolution, Molecular;
Mutation;
Tumor Microenvironment
- From:
Chinese Journal of Lung Cancer
2024;26(12):943-949
- CountryChina
- Language:Chinese
-
Abstract:
So far, the monoclonal hypothesis of tumor occurrence and development cannot be justified. The genetic diversity selection hypothesis for the occurrence and development of lung cancer links Mendelian genetics with Darwin's theory of evolution, suggesting that the genetic diversity of tumor cell populations with polyclonal origins-monoclonal selection-subclonal expansion is the result of selection pressure. Normal cells acquire mutations in oncogenic driver genes and have a selective advantage over other cells, becoming tumor initiating cells; In the interaction with the tumor microenvironment (TME), the vast majority of initiating cells are recognized and killed by the human immune system. If immune escape occurs, the incidence of malignant tumors will greatly increase, and subclonal expansion, intratumour heterogeneity, etc. will occur. This article proposed the hypothesis of genetic diversity selection and analyzed its clinical significance.
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