Research Progress of LncRNA SNHGs in Regulating the Biological Behavior
of Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2023.102.41
- Author:
Xincen CAO
1
;
Liang CHEN
1
Author Information
1. Department of Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
- Publication Type:Journal Article
- Keywords:
Long non-coding RNA;
Lung neoplasms;
Small nucleolar RNA host gene
- MeSH:
Humans;
Carcinoma, Non-Small-Cell Lung/pathology*;
Lung Neoplasms/pathology*;
RNA, Long Noncoding/genetics*;
Quality of Life;
China;
Cell Proliferation/genetics*;
Gene Expression Regulation, Neoplastic;
Cell Movement;
MicroRNAs/genetics*;
Cell Line, Tumor
- From:
Chinese Journal of Lung Cancer
2023;26(11):851-862
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the malignant tumors with the highest incidence and mortality rate in China, and its occurrence and development mechanism and treatment methods are the current research focuses. In recent years, the emergence of drugs targeting various tumor driver genes has significantly improved patients' survival and quality of life, setting off a wave of research on new therapeutic targets. Among them, long non-coding RNA (lncRNA) plays a crucial role in the malignant behavior of tumors, which has attracted widespread attention. Shown by a large number of studies, partial members of lncRNA small nucleolar RNA host gene (SNHG) family are aberrantly expressed in many maliglant tumors including non-small cell lung cancer (NSCLC) and participate in cell proliferation, invasion and migration, which may act as a new diagnostic and prognostic biomarker and can be a therapeutic target of NSCLC. In this review, we comprehensively summarize and explore the recent investigation of SNHGs in NSCLC in order to provide new ideas for the diagnosis and treatment of NSCLC.
.
