Research Advances of RAD51AP1 in Tumor Progression and Drug Resistance.
10.3779/j.issn.1009-3419.2023.102.34
- Author:
Renwang LIU
1
;
Mingbiao LI
2
;
Zixuan HU
1
;
Zuoqing SONG
1
;
Jun CHEN
1
Author Information
1. Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
2. Tianjin Key Laboratory of Lung Cancer
Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin 300052, China.
- Publication Type:Journal Article
- Keywords:
Cancer stem cells;
Drug resistance;
RAD51AP1
- MeSH:
Humans;
DNA-Binding Proteins/metabolism*;
RNA-Binding Proteins/metabolism*;
Lung Neoplasms;
DNA Repair;
Genomic Instability;
Rad51 Recombinase/metabolism*
- From:
Chinese Journal of Lung Cancer
2023;26(9):701-708
- CountryChina
- Language:Chinese
-
Abstract:
The genomic instability may lead to an initiation of cancer in many organisms. Homologous recombination repair (HRR) is vital in maintaining cellular genomic stability. RAD51 associated protein 1 (RAD51AP1), which plays a crucial role in HRR and primarily participates in forming D-loop, was reported as an essential protein for maintaining cellular genomic stability. However, recent studies showed that RAD51AP1 was significantly overexpressed in various cancer types and correlated with poor prognosis. These results suggested that RAD51AP1 may play a significant pro-cancer effect in multiple cancers. The underlying mechanism is still unclear. Cancer stemness-maintaining effects of RAD51AP1 might be considered as the most reliable mechanism. Meanwhile, RAD51AP1 also promoted resistance to radiation therapy and chemotherapy in many cancers. Thus, researches focused on RAD51AP1, and its regulatory molecules may provide new targets for overcoming cancer progression and treatment resistance. Here, we reviewed the latest research on RAD51AP1 in cancers and summarized its differential expression and prognostic implications. In this review, we also outlined the potential mechanisms of its pro-cancer and drug resistance-promoting effects to provide several potential directions for further research.
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