Research Progress of Iron Metabolism in Disease Progression and Drug Resistance of Multiple Myeloma--Review.
10.19746/j.cnki.issn.1009-2137.2023.06.050
- Author:
Yan-Ying LI
1
;
Liu-Yun ZHANG
1
;
Yun-Hui XIANG
1
;
Juan ZHANG
2
Author Information
1. School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, China.
2. School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, China.E-mail: zhangjuan82@126.com.
- Publication Type:Journal Article
- Keywords:
ferroptosis;
bortezomib resistance;
iron metabolism;
multiple myeloma
- MeSH:
Humans;
Autophagy;
Disease Progression;
Iron/metabolism*;
Multiple Myeloma;
Drug Resistance, Neoplasm
- From:
Journal of Experimental Hematology
2023;31(6):1916-1920
- CountryChina
- Language:Chinese
-
Abstract:
Iron metabolism is involved in the development and drug resistance of many malignancies, including multiple myeloma (MM). Based on recent studies on iron metabolism and MM, this paper reviews the relationship between iron metabolism and disease process of MM in terms of iron overload leading to ferroptosis in MM cells, the role of iron deficiency in oxidative respiration and proliferation of MM cells, and the interaction between ferroptosis and autophagy in the disease process. The mechanisms by which iron metabolism-related substances lead to MM cells' resistance to proteasome inhibitors (PI) through inducing redox imbalance and M2 macrophage polarization are also briefly described, aiming to provide a theoretical basis for the application of iron metabolism-related drugs to the clinical treatment of MM patients.
