Investigation of Antigen and Gene Frequency of Kell(K) and Rh(D) Blood Groups in Xinjiang.
10.19746/j.cnki.issn.1009-2137.2023.06.035
- Author:
Fei LI
1
;
Li SHI
2
;
Rong ZHU
3
;
Bo XIE
4
;
Hai-Yan YE
5
;
Xin-Hua ZHOU
6
;
Jun WEN
1
;
Wei CHEN
7
Author Information
1. Department of Blood Transfusion, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.
2. Department of Blood Transfusion, Friendship Hospital of Xinjiang's Ili Kazak Autonomous Prefecture, Ili 835000, Xinjiang Uygur Autonomous Region, China.
3. Department of Blood Transfusion, People's Hospital of Kizilesu Kirgiz, Kizilsu Kirgiz Autonomous Prefecture 845350, Xinjiang Uygur Autonomous Region, China.
4. Department of Blood Transfusion, Xinjiang Hami Central Hospital, Hami 839000, Xinjiang Uygur Autonomous Region, China.
5. Department of Blood Transfusion, The First People's Hospital Kashgar, Kashgar 844000, Xinjiang Uygur Autonomous Region, China.
6. Department of Blood Transfusion, Xinjiang Hotan District First People's Hospital, Hotan 848000, Xinjiang Uygur Autonomous Region, China.
7. Department of Blood Transfusion, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China,E-mail:29286889@qq.com.
- Publication Type:Journal Article
- Keywords:
Kell blood type;
Rh blood type;
Xinjiang region;
antigen frequency;
gene frequency
- MeSH:
Female;
Humans;
Male;
Asian People;
China;
Ethnicity;
Gene Frequency;
Kell Blood-Group System/genetics*;
Rh-Hr Blood-Group System/genetics*
- From:
Journal of Experimental Hematology
2023;31(6):1825-1830
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the phenotypes and gene frequencies of Kell blood group system K antigen and Rh blood group system D antigen in Xinjiang, and summarize and understand the distribution of Kell(K) blood type and Rh(D) blood type in this area.
METHODS:A total of 12 840 patients who met the inclusion criteria during physical examination and treatment in our hospital and 18 medical institutions in our district from January 1, 2019 to December 31, 2019 were collected for identification of Kell blood group system K antigen and Rh blood group System D antigen, and the distribution of K and D blood groups in different regions, genders and nationalities were investigated and statistically analyzed.
RESULTS:The proportion of K positive in the samples was 1.39%, the highest was 1.91% in southern Xinjiang, and the lowest was 1.03% in northern Xinjiang(P<0.01). The proportion of Rh(D) negative samples was 2.75% and the gene frequency was 16.64%. The proportion of Rh(D) negative samples was 4.03% and the gene frequency was 20.10% in southern Xinjiang, followed by eastern Xinjiang and the lowest in northern Xinjiang (P<0.01). The frequency of K antigen in Uygur nationality was the highest, reaching 2.16%, Kirgiz 1.54%, and the distribution trend of D/d antigen was similar to that of K antigen. Among women, the K positive frequency of Kazak nationality was slightly higher than that of Mongolian nationality. The highest proportion of K positive in Uygur women was 2.38%, which was higher than that in Uygur men (1.86%). The frequency of d phenotype in Kazak women was 3.15%, which was higher than that in Kirgiz （2.89%） (P<0.01).
CONCLUSION:The distributions of Kell(K) and Rh(D) blood groups in northern and southern Xinjiang and eastern Xinjiang had its own unique characteristics and differences. There are significant differences in blood group distribution among different ethnic groups and gender groups. In the future, k antigen detection can be included to further improve the investigation on the distribution of Kell blood group system in this region.
