Levels and Clinical Significances of sPD-1 and sPD-L1 in Peripheral Blood of Lymphoma Patients.
10.19746/j.cnki.issn.1009-2137.2023.06.020
- Author:
Xiao-Liu LIU
1
;
Ping HE
2
;
Jian LEI
3
;
Li-Xin ZOU
4
;
Lang PENG
4
Author Information
1. Department of Hematology, Changsha Hospital of Hunan Normal University, Changsha 410006, Hunan Province, China.E-mail: liuxiaoliu_2008@163.com.
2. Department of Neurology, The Second People's Hospital of Hunan Province, Changsha 410007, Hunan Province, China.
3. Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410006, Hunan Province, China.
4. Department of Hematology, Changsha Hospital of Hunan Normal University, Changsha 410006, Hunan Province, China.
- Publication Type:Journal Article
- Keywords:
lymphoma;
soluble programmed cell death ligand 1;
soluble programmed cell death protein 1
- MeSH:
Humans;
Clinical Relevance;
Prognosis;
T-Lymphocyte Subsets/metabolism*;
Lymphoma, T-Cell, Peripheral;
Enzyme-Linked Immunosorbent Assay;
B7-H1 Antigen/metabolism*
- From:
Journal of Experimental Hematology
2023;31(6):1733-1738
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the levels of soluble programmed cell death protein 1 (sPD-1) and soluble programmed cell death ligand 1 (sPD-L1) in peripheral blood of lymphoma patients, and reveal their clinical significances.
METHODS:The peripheral blood specimens and clinical data of 64 newly diagnosed lymphoma patients and 30 healthy volunteers were collected. The levels of sPD-1 and sPD-L1 were detected by enzyme-linked immunosorbent assay (ELISA), and their correlations with clinical characteristics of the patients including pathological type, stage, lactate dehydrogenase (LDH) level, T cell subsets were analyzed.
RESULTS:The levels of both sPD-1 and sPD-L1 in peripheral blood of lymphoma patients were higher than those of normal controls (P <0.05). There were no significant differences in sPD-1 and sPD-L1 levels in peripheral blood between Hodgkin lymphoma and non-Hodgkin lymphoma patients. Different pathological subtypes of lymphoma had different levels of sPD-1. The level of sPD-1 in patients with T-cell lymphoma was higher than that in patients with B-cell lymphoma (P =0.001). The levels of both sPD-1 and sPD-L1 in patients with Ann Arbor stage III and IV were higher than those in patients with stage I and II (P <0.05). The level of sPD-L1 in patients with abnormally increased LDH was higher than that in patients with normal LDH (P =0.001), but there was no significant difference in sPD-1 level. T cell subset analysis showed that the level of sPD-L1 was negatively correlated to CD4+ T cell content (r =-0.265).
CONCLUSION:The levels of sPD-1 and sPD-L1 in peripheral blood of lymphoma patients are related to the pathological type, Ann Arbor stage, LDH content and T cell subsets, and will be potential biomarkers in predicting the prognosis of lymphoma.
