The Expression Level and Diagnostic Value of Serum Free Light Chain in B-Cell Non-Hodgkin Lymphoma.
10.19746/j.cnki.issn.1009-2137.2023.06.015
- Author:
Yan WANG
1
;
Hui WANG
1
;
Jian-Fu ZHANG
1
;
Jian-Yong LI
1
;
Ning-Han ZHANG
1
;
Rong WANG
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People Hospital, Nanjing 210029, Jiangsu Province, China.
2. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People Hospital, Nanjing 210029, Jiangsu Province, China,E-mail: viviwr@sina.com.
- Publication Type:Journal Article
- Keywords:
B-cell non-Hodgkin lymphoma;
bone marrow infiltration;
serum free light chain
- MeSH:
Humans;
Retrospective Studies;
Immunoglobulin Light Chains;
Lymphoma, B-Cell/diagnosis*
- From:
Journal of Experimental Hematology
2023;31(6):1701-1705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression level and the diagnostic value of serum free light chain in B-cell non-Hodgkin's lymphoma (B-NHL).
METHODS:We retrospectively analyzed the results of serum free light chain (sFLC) of 394 newly treated B-NHL patients in our hospital from January 2014 to December 2021 and compared the secretion levels of sFLC among different subtypes of B-NHL. The value of sFLC secretion levels in the diagnosis of WM was evaluated using ROC.
RESULTS:Increased proportion of sFLC, abnormal ratio of sFLC (κ / λ) and the secretion levels of sFLC (κ+λ) were different in different B-NHL subtypes, Waldenstrom's macroglobulinemia (WM) had the highest proportion of elevated sFLC(82.68%) and abnormal sFLC(κ/ λ)(87.0%), the proportion of FL(18.0%) and DLBCL patients(12.8%) with elevated sFLC was lower (P<0.05). The expression levels of sFLC can helpful in the diagnosis of WM (AUC=0.874，P<0.001， 95% CI: 0.779-0.970). At the same time, higher sFLC levels and sFLC cloning patterns predicted the possibility of bone marrow infiltration of lymphoma.
CONCLUSION:The serum free light chains is common in patients with B-NHL. The elevated level and type of free light chain are associated with the type of lymphoma, and the patients with bone marrow infiltration have higher sFLC（κ+ λ） expression level.
