Clinical Features and Prognostic Factors of Patients with Primary Cutaneous Lymphoma.
10.19746/j.cnki.issn.1009-2137.2023.05.020
- Author:
Nuer-Maimaiti REXIDAN
1
;
Pu-Li WANG
2
;
Zhi-Rong ZHANG
3
;
Dan CHEN
1
;
Zhi-Yong CUI
3
;
Jian-Bin YANG
2
;
Tian-You JIANG
4
;
Chen TIAN
5
Author Information
1. Department of Hematology, Hotan District People's Hospital, Hotan 848000, Xinjiang Uygur Autonomous Region, China.
2. Department of Emergency, Heji Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi Province, China.
3. Department of Oncology, Hotan District People's Hospital, Hotan 848000, Xinjiang Uygur Autonomous Region, China.
4. Department of Lymphoma, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China.
5. Department of Oncology, Hotan District People's Hospital, Hotan 848000, Xinjiang Uygur Autonomous Region, China.E-mail: tianchen@tjmuch.com.
- Publication Type:Journal Article
- Keywords:
T-cell;
cutaneous lymphoma;
prognosis;
β
- MeSH:
Humans;
Prognosis;
Retrospective Studies;
Remission Induction;
Lymphoma
- From:
Journal of Experimental Hematology
2023;31(5):1379-1384
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To retrospectively analyze the clinical characteristics and prognostic factors of patients with primary cutaneous lymphoma.
METHODS:The clinical data of 22 patients with primary cutaneous lymphoma admitted to Xinjiang Hotan District People's Hospital, Heji Hospital affiliated to Changzhi Medical College and the Fifth Medical Center of PLA General Hospital from January 2013 to June 2021 were retrospectively analyzed.
RESULTS:The incidence of primary cutaneous T cell and NK/T cell lymphoma was about 91.9/100 000, and the incidence of primary cutaneous B cell lymphoma was about 14.5/100 000. The overall survival (OS) of patients aged ≥65 years was significantly shorter than that of patients younger than 65 years (P <0.05). Patients with elevated β2-microglobulin (β2-MG) had shorter OS and progression-free survival (PFS) (both P <0.05). Patients who achieved complete/partial response after initial treatment had longer OS than those with stable or progressive disease (P <0.05). There were significant differences in OS and PFS among patients with different pathological types of primary cutaneous lymphoma that originated from T and NK/T cells, the OS and PFS of patients with mycosis fungoides were longer than those of patients with other pathological types (both P <0.05). In addition, disease stage might also affect the PFS of the patients (P =0.056).
CONCLUSION:The age, disease stage, β2-MG level, pathological type and remission state after treatment of the patients were related to the clinical prognosis.
