Recent Progress on Pharmaceutical Properties of Extracellular Vesicles from Mesenchymal Stem Cells--Review.
10.19746/j.cnki.issn.1009-2137.2023.04.050
- Author:
Yu-Shuang LIU
1
;
Yuan SUN
1
;
Zi-Kuan GUO
2
Author Information
1. Department of Hematology,Beijing Jingdu Children's Hospital, Beijing 102208, China.
2. Department of Central Laboratory,Beijing Jingdu Children's Hospital, Beijing 102208, China.
- Publication Type:Review
- Keywords:
extracellular vesicle;
mesenchymal stem cell;
micro-RNA;
pharmaceutical properties
- MeSH:
Humans;
Extracellular Vesicles;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Mesenchymal Stem Cell Transplantation/methods*;
Mesenchymal Stem Cells;
Pharmaceutical Preparations
- From:
Journal of Experimental Hematology
2023;31(4):1247-1251
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSCs) have been officially approved in many countries to treat graft-versus-host disease, autoimmune disorders and those associated with tissue regeneration after hematopoietic stem cell transplantation. Studies in recent years have confirmed that MSC acts mainly through paracrine mechanism, in which extracellular vesicles secreted by MSC (MSC-EV) play a central role. MSC-EV has overwhelming advantages over MSC itself in the setting of adverse effects in clinical application, indicating that MSC-EV might take the place of its parent cells to be a potentially therapeutic tool for "cell-free therapy". The pharmaceutical properties of MSC-EV largely depend upon the practical and optimal techniques including large-scale expansion of MSC, the modification of MSC based on the indications and the in vivo dynamic features of MSC-EV, and the methods for preparing and harvesting large amounts of MSC-EV. The recent progresses on the issues above will be briefly reviewed.
