Research Progress on the Mechanism of Macrophages Regulating Hematopoiesis in Bone Marrow Microenvironment--Review.
10.19746/j.cnki.issn.1009-2137.2023.04.049
- Author:
Yu-Han WANG
1
,
2
;
Yue LI
1
,
2
;
Shuang DING
3
,
4
Author Information
1. School of Medical Technology, Xuzhou Medical University
2. The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
3. Department of Clinical Laboratory, Xuzhou Medical University
4. The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.E-mail: ds1012@126.com.
- Publication Type:Journal Article
- Keywords:
hematopoietic microenvironment;
hematopoietic regulation;
hematopoietic stem cell transplantation;
macrophage
- MeSH:
Humans;
Bone Marrow/metabolism*;
Hematopoietic Stem Cells/physiology*;
Hematopoiesis/physiology*;
Stem Cell Niche;
Macrophages/metabolism*
- From:
Journal of Experimental Hematology
2023;31(4):1242-1246
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow macrophage is an important component of bone marrow microenvironment, which is closely related to hematopoietic regulation and hematopoietic stem cell transplantation(HSCT). Recent studies have shown that bone marrow macrophage is an important part of hematopoietic stem cell niche, which can help regulate the mobilization and function of hematopoietic stem/progenitor cells. After HSCT, the microenvironment of bone marrow is damaged and a large number of macrophages infiltrate into the bone marrow. Regulating the macrophage-related signal pathways can promote the recovery of hematopoiesis and the reconstruction of hematopoietic function. Co-culture of macrophages and hematopoietic stem cells (HSC) in vitro significantly increased the number of HSCs and their ability of clone formation, which suggests that macrophages play an important role in the regulation of hematopoiesis in the hematopoietic microenvironment of bone marrow. This paper reviews the recent research progress on the role of macrophages in bone marrow hematopoietic microenvironment.
