Research Progress on Capillary Leak Syndrome Associated with Hematopoietic Stem Cell Transplantation--Review.
10.19746/j.cnki.issn.1009-2137.2023.04.048
- Author:
Chang LIU
1
,
2
;
Shao-Yan HU
1
,
3
Author Information
1. Jiangsu Children's Hematology and Oncology Center
2. Department of Hematology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
3. Department of Hematology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.E-mail: hushaoyan@suda.edu.cn.
- Publication Type:Journal Article
- Keywords:
capillary leak syndrome;
hematopoietic stem cell transplantation;
high permeability;
hypercytokinemia;
treatment
- MeSH:
Humans;
Capillary Leak Syndrome/diagnosis*;
Endothelial Cells;
Hematopoietic Stem Cell Transplantation/adverse effects*
- From:
Journal of Experimental Hematology
2023;31(4):1237-1241
- CountryChina
- Language:Chinese
-
Abstract:
Capillary leak syndrome (CLS) is a clinical syndrome characterized by impairment of vascular endothelial barrier function, increased vascular permeability, and reversible systemic edema. It is one of the early fatal complications after hematopoietic stem cell transplantation. So far, the exact pathogenesis of CLS has not been elucidated, and the diagnostic criteria and treatment methods have not been unified. At present, it is believed that the fundamental cause of CLS is hypercytokinemia, and the core factor is high permeability of vascular endothelial cells. According to the clinical manifestations, the natural course of CLS can be divided into prodrome, leakage and recovery stages. As far as treatment is concerned, symptomatic and supportive treatment is dominant according to different characteristics of each stage. In this review, the pathogenesis, clinical manifestations, diagnosis and treatment of hematopoietic stem cell transplant-associated CLS were briefly summarized.
