Clinical Characteristics and Risk Factors for 30-Day Mortality in Patients with Hematologic Diseases Infected by Carbapenem-Resistant Organisms.
10.19746/j.cnki.issn.1009-2137.2023.04.041
- Author:
Xin-Yue CHEN
1
;
Chen-Rui HOU
2
;
Jie ZHAO
3
;
Shao-Long HE
3
;
Xin-Yi LU
3
;
Xiao-Ye GUO
4
;
Rui-Xue WANG
2
;
Liang-Ming MA
3
;
Jun-Ni WEI
1
;
Wei-Wei TIAN
5
Author Information
1. School of Public Health, Shanxi Medical University, The Third Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
2. Department of Clinical Laboratory, The Third Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
3. Department of Hematology, The Third Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
4. Department of Information, The Third Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
5. School of Public Health, Shanxi Medical University, Department of Hematology, The Third Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.E-mail: tianweiwei@yeah.net.
- Publication Type:Journal Article
- Keywords:
carbapenem-resistant organism;
hematologic disease;
infection;
prognosis;
risk factors
- MeSH:
Humans;
Carbapenems/pharmacology*;
Retrospective Studies;
Creatinine;
Hematologic Diseases;
Risk Factors;
Imipenem;
Albumins
- From:
Journal of Experimental Hematology
2023;31(4):1199-1204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical characteristics of hospitalized patients with hematologic diseases complicated with carbapenem-resistant organisms (CRO) infection and analyze the risk factors of 30-day all-cause mortality.
METHODS:The clinical data and laboratory test data of 77 hospitalized patients with hematologic diseases complicated with CRO infection in department of hematology of the Third Hospital of Shanxi Medical University from January 2015 to December 2020 were retrospectively analysed, the risk factors of 30-day all-cause mortality after CRO infection were analyzed by multivariate logistic regression.
RESULTS:Among the total of 77 patients with hematologic diseases complicated with CRO infection, 29 died and 48 survived within 30 days of infection, with a case fatality rate of 37.66%. A total of 93 strains of CRO were isolated from these patients, of which Acinetobacter baumannii had the highest detection rate (25.81%, 24/93), followed by Pseudomonas aeruginosa (18.28%, 17/93). The lung was the most common site of CRO infection. The detected pathogens were highly resistant to carbapenems, and 64.52% (60/93) of the pathogens were resistant to imipenem with minimum inhibitory concentration (MIC)≥16 μg/ml. The results of the univariate analysis showed that albumin concentration <25 g/L (P =0.048), serum creatinine concentration≥120 μmol/L (P =0.023), age-adjusted Charlson comorbidity index (ACCI) (P =0.037) and primary treatments (supportive treatment, immunosuppressive therapy, chemotherapy, HSCT) (P =0.048) were significantly associated with 30-day all-cause mortality after infection. The results of multivariate logistic regression analysis showed that when CRO infection confirmed, albumin concentration <25 g/L (P =0.014, OR=6.171), serum creatinine concentration≥120 μmol/L (P =0.009, OR=10.867) were independent risk factors for 30-day mortality of patients with hematologic diseases complicated with CRO infection.
CONCLUSION:The mortality rate of CRO-infected patients with hematologic diseases is high. The detected pathogenic bacteria are highly resistant to imipenem. The albumin concentration <25 g/L and the serum creatinine concentration≥ 120 μmol/L at diagnosis of CRO infection were independent risk factors for 30-day mortality of the patients with hematologic diseases.
