Research progress on the roles of neurovascular unit in stroke-induced immunosuppression.
10.3724/zdxbyxb-2023-0144
- Author:
Mengqin ZHOU
1
;
Peng SU
2
;
Jingyan LIANG
2
;
Tianqing XIONG
3
Author Information
1. Institute of Translational Medicine, Yangzhou University Medical College, Yangzhou 225009, Jiangsu Province, China. zhoumengq199@163.com.
2. Institute of Translational Medicine, Yangzhou University Medical College, Yangzhou 225009, Jiangsu Province, China.
3. Institute of Translational Medicine, Yangzhou University Medical College, Yangzhou 225009, Jiangsu Province, China. xiongtianqing@126.com.
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Immunosuppression;
Neurovascular unit;
Review
- MeSH:
Humans;
Endothelial Cells;
Stroke;
Neurons/physiology*;
Immunosuppression Therapy/adverse effects*;
Cerebral Infarction
- From:
Journal of Zhejiang University. Medical sciences
2023;52(5):662-672
- CountryChina
- Language:Chinese
-
Abstract:
A complex pathophysiological mechanism is involved in brain injury following cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular structure consisting of neurons, endothelial cells, pericyte, astrocyte, microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly participates in the regulation of inflammatory immune process. The components of NVU promote inflammatory overreaction and synergize with the overactivation of autonomic nervous system to initiate stroke-induced immunodepression (SIID). SIID can alleviate the damage caused by inflammation, however, it also makes stroke patients more susceptible to infection, leading to systemic damage. This article reviews the mechanism of SIID and the roles of NVU in SIID, to provide a perspective for reperfusion, prognosis and immunomodulatory therapy of cerebral infarction.
