Roles of long non-coding RNAs in digestive tract cancer and their clinical application.
10.3724/zdxbyxb-2023-0169
- Author:
Zhendong ZHANG
1
;
Xiaoping WANG
2
Author Information
1. School of Medicine, Xizang Minzu University, Key Laboratory of High Altitude Hypoxia Environment and Life Health, Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Tibetan Materia Medica of Tibetan Medical Research Center of Tibet, Xianyang 712082, Shaanxi Province, China. zhangzhendong360@163.com.
2. School of Medicine, Xizang Minzu University, Key Laboratory of High Altitude Hypoxia Environment and Life Health, Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Tibetan Materia Medica of Tibetan Medical Research Center of Tibet, Xianyang 712082, Shaanxi Province, China. xpwang@xzmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Digestive tract cancer;
Lipid metabolism;
Long non-coding RNA;
Review;
Signaling pathway;
Targeted therapy
- MeSH:
Humans;
RNA, Long Noncoding/genetics*;
Gastrointestinal Neoplasms/genetics*;
Apoptosis;
Liver Neoplasms
- From:
Journal of Zhejiang University. Medical sciences
2023;52(4):451-459
- CountryChina
- Language:English
-
Abstract:
Long non-coding RNAs (lncRNAs) are strongly related to the occurrence and development of digestive tract cancer in human. Firstly, lncRNAs target and regulate the expression of downstream cancer genes to affect the growth, metastasis, apoptosis, metabolism and immune escape of cancer cells. Secondly, lncRNAs are considered to be important regulating factors for lipid metabolism in cancer, which is related to signaling pathways of adipogenesis and involved in the occurrence and development of digestive tract cancer. Finally, lncRNAs have application value in the diagnosis and treatment of digestive tract cancer. For example, lncRNAMALAT1 has been reported as a target for diagnosis and treatment of hepatocellular carcinoma. This article reviews current progress on the regulatory role of lncRNAs in digestive tract cancer, to provide references for the research and clinical application in the prevention and treatment of digestive tract cancer.
