Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis.
10.7499/j.issn.1008-8830.2307065
- Author:
Reaila JIANATI
1
;
Xi-Xi LIU
1
;
Xue-Jun ZHU
Author Information
1. Department of Hematology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China (Zhu X-J, Email: zhuxuejun@njucm.edu. cn).
- Publication Type:Journal Article
- Keywords:
Etiology;
Henoch-Schönlein purpura;
Immunoglobulin A vasculitis;
Pathogenesis
- MeSH:
Humans;
IgA Vasculitis;
Antigen-Antibody Complex;
Immunoglobulin A/genetics*
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(12):1287-1292
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schönlein purpura, has complex etiology and pathogenesis which have not been fully clarified. The latest research shows that SARS-CoV-2 and related vaccines, human papilloma vaccine, and certain biological agents can also induce IgAV. Most studies believe that the formation of galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complex plays a crucial role in the pathogenesis of IgAV. It is hypothesized that the pathogenesis of IgAV is associated with the binding of IgA1 to anti-endothelial cell antibodies. In addition, genetics also constitutes a major focus of IgAV research. This article reviews the new advances in the etiology of IgAV and summarizes the role of Gd-IgA1, Gd-IgA1-containing immune complex, anti-endothelial antibody, IgA1 conjugates, T lymphocyte immunity, and genetic factors in the pathogenesis of IgAV.
