Research advances in genetic polymorphisms in Kawasaki disease.
10.7499/j.issn.1008-8830.2308073
- Author:
Ming-Xing DONG
1
;
Xi-Xia WANG
1
;
Fu-Yong JIAO
;
Wei-Hua ZHANG
1
Author Information
1. Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China/Xianyang Children's Hospital, Xianyang,Shaanxi 712000, China (Zhang W-H, Email: xiangyuelanda2006@126. com).
- Publication Type:Journal Article
- Keywords:
Coronary artery lesion;
Genetic polymorphism;
Kawasaki disease;
Susceptibility
- MeSH:
Child;
Humans;
Mucocutaneous Lymph Node Syndrome/complications*;
Genome-Wide Association Study;
Genetic Predisposition to Disease;
Polymorphism, Genetic;
Coronary Vessels/pathology*;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(12):1234-1238
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease (KD) is a systemic inflammatory vascular disorder that predominantly affects children and is the leading cause of acquired heart disease in children. Although the etiology of this disease remains unclear, genome-wide association and genome-wide linkage studies have shown that some susceptible genes and chromosomal regions are associated with the development and progression of KD. With the advancement of high-throughput DNA sequencing techniques, more and more genomic information related to KD is being discovered. Understanding the genes involved in the pathogenesis of KD may provide novel insights into the diagnosis and treatment of KD. By analyzing related articles and summarizing related research advances, this article mainly discusses the T cell activation-enhancing genes that have been confirmed to be closely associated with the development and progression of KD and reveals their association with the pathogenesis of KD and coronary artery lesions.
