Diagnostic significance and considerations of growth hormone stimulation testing and insulin-like growth factor 1 in growth hormone deficiency.
10.7499/j.issn.1008-8830.2308076
- Author:
Tang LI
1
Author Information
1. Department of Pediatric Endocrinology and Metabolism, Women and Children's Hospital, Qingdao University, Qingdao, Shandong 266000, China (Email: drlitang@hotmail. com).
- Publication Type:Journal Article
- Keywords:
Child;
Growth hormone;
Growth hormone deficiency;
Growth hormone stimulation testing;
Insulin-like growth factor 1
- MeSH:
Child;
Humans;
Growth Hormone/metabolism*;
Insulin-Like Growth Factor I/metabolism*;
Insulin-Like Peptides;
Insulin-Like Growth Factor Binding Protein 3;
Human Growth Hormone/metabolism*;
Dwarfism, Pituitary/diagnosis*
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(12):1193-1197
- CountryChina
- Language:Chinese
-
Abstract:
The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is an essential component of the hypothalamic-pituitary growth hormone axis and plays a crucial role in childhood growth and development. Disruptions and abnormalities in the GH/IGF-1 signaling pathway and its pathways typically manifest as short stature in children. Children with short stature often undergo GH stimulation testing and IGF-1 level measurements to differentiate growth hormone deficiency (GHD) from other causes of growth delay. This article aims to analyze and elucidate the values of GH stimulation testing and IGF-1 measurement, providing reference for the diagnosis of GHD in children.
