Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children.
10.7499/j.issn.1008-8830.2305025
- Author:
Yu-Qiao DIAO
1
;
Jian WANG
1
;
Xiu-Li ZHU
1
;
Jian CHEN
1
;
Yu ZHENG
1
;
Lian JIANG
1
;
Yue-Ping LIU
;
Ruo-Heng DAI
1
;
Yi-Wei YAN
1
Author Information
1. Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
- Publication Type:Journal Article
- Keywords:
Child;
Clinicopathological characteristic;
Hypoxia-inducible factor-1α;
Jumonji domain-containing protein 2B;
Non-Hodgkin's lymphoma;
Prognosis
- MeSH:
Humans;
Child;
Hypoxia-Inducible Factor 1, alpha Subunit;
Prognosis;
Hypoxia;
Lymphoma, Non-Hodgkin
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(11):1150-1155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children.
METHODS:Immunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed.
RESULTS:The positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group (P<0.05). The expression of JMJD2B and HIF-1α was correlated with serum lactate dehydrogenase levels and the risk of international prognostic index in children with NHL (P<0.05). The expression of JMJD2B was positively correlated with the HIF-1α expression in children with NHL (rs=0.333, P=0.024).
CONCLUSIONS:JMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL.
