Mechanism of action and exogenous supplementation of vitamin D in Crohn's disease.
10.7499/j.issn.1008-8830.2212064
- Author:
Yu XIA
;
Juan ZHOU
1
;
Hong-Mei ZHAO
1
;
Jie-Yu YOU
1
Author Information
1. Department of Gastroenterology and Nutrition, Hunan Children's Hospital, Changsha 410007, China.
- Publication Type:Journal Article
- Keywords:
Child;
Crohn's disease;
Mechanism of action;
Vitamin D
- MeSH:
Humans;
Calcium, Dietary;
Crohn Disease/drug therapy*;
Dietary Supplements;
Infliximab;
Vitamin D/therapeutic use*
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(8):870-876
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D can not only regulate calcium and phosphorus metabolism, but also exert an immunoregulatory effect. Vitamin D deficiency is common in patients with Crohn's disease (CD). Studies have shown that vitamin D is associated with CD and other autoimmune diseases and can improve the condition of patients with CD and promote their recovery by regulating intestinal immunity, repairing the intestinal mucosal barrier, inhibiting intestinal fibrosis, enhancing the response to infliximab, and regulating intestinal microbiota. Exogenous vitamin D supplementation can induce disease remission while increasing the serum level of vitamin D. However, only a few randomized, double-blind, and placebo-controlled trials have investigated the therapeutic effect of vitamin D in CD, and the optimal form of vitamin D supplementation, the specific dosage of vitamin D supplementation, and the optimal serum maintenance concentration of vitamin D remain to be clarified. This article mainly discusses the mechanism of action of vitamin D in CD and the beneficial effect of exogenous vitamin D supplementation on CD.
