Role of tumor-associated immune cells in prostate cancer: angel or devil?

Author: Shui-Qing WU ¹ ; Hao SU ¹ ; Yin-Huai WANG ¹ ; Xiao-Kun ZHAO ¹
Author Information

1. Department of Urology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Publication Type:Review
Keywords: immune tolerance; prostate cancer; tumor associated immune cells; tumor microenvironment
MeSH: Disease Progression; Humans; Lymphocytes, Tumor-Infiltrating/pathology*; Macrophages/pathology*; Male; Neutrophils/pathology*; Prostatic Neoplasms/therapy*; Prostatic Neoplasms, Castration-Resistant/therapy*
From: Asian Journal of Andrology 2019;21(5):433-437
CountryChina
Language:English
Abstract: Prostate cancer is the most common malignancy in the reproductive system of older males. Androgen deprivation therapy (ADT) is an important treatment for prostate cancer patients. However, almost all prostate cancer patients unavoidably progress to the castration-resistant stage after ADT treatment. Recent studies have shown that tumor-associated immune cells play major roles in the initiation, progression, and metastasis of prostate cancer. Various phenotypes of tumor-associated immune cells have tumor-promoting or antitumor functions mediated by interacting with tumor cells. Here, we review the current knowledge of tumor-associated immune cells in prostate cancer.