Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression.
- Author:
Li-Ning JIANG
1
;
Ya-Bin LIU
1
;
Bing-Hui LI
1
Author Information
- Publication Type:Journal Article
- Keywords: dietary supplement; inflammation; lycopene; prostate cancer
- From: Asian Journal of Andrology 2018;21(1):80-85
- CountryChina
- Language:English
- Abstract: Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-α (TNF-α), in lycopene-treated cells were also reduced by lycopene treatment. With the increasing dose of lycopene, the survival of mice bearing prostate cancer xenografts was significantly improved (P < 0.01), and the tumor burden was significantly reduced (P < 0.01). Our results indicate that lycopene is a promising chemotherapy drug, which inhibits prostate cancer progression by suppressing the inflammatory response.
