Iodinated Contrast Media Can Induce Long-Lasting Oxidative Stress in Hemodialysis Patients.
10.3349/ymj.2013.54.6.1438
- Author:
Seun Deuk HWANG
1
;
Yoon Ji KIM
;
Sang Heun LEE
;
Deok Kyu CHO
;
Yun Hyeong CHO
;
Sung Jin MOON
;
Sang Choel LEE
;
Soo Young YOON
Author Information
1. Division of Nephrology, Department of Internal Medicine, Kwandong University Medical College, Gangneung, Korea. diva502@kd.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Oxidative stress;
contrast media;
hemodialysis
- MeSH:
Aged;
Contrast Media/*adverse effects;
Female;
Humans;
Male;
Middle Aged;
Oxidative Stress/*drug effects;
Renal Dialysis/*adverse effects
- From:Yonsei Medical Journal
2013;54(6):1438-1446
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population. MATERIALS AND METHODS: We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days. RESULTS: In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure. CONCLUSION: Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.
