The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells.

Zhuo Chen; Meng-wei Yao; Xiang AO; Qing-jia Gong; Yi Yang; Jin-xia Liu; Qi-zhou Lian; Xiang XU; Ling-jing Zuo

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The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells.

Author: Zhuo CHEN ^{1
,

2} ; Meng-Wei YAO ³ ; Xiang AO ⁴ ; Qing-Jia GONG ⁵ ; Yi YANG ⁶ ; Jin-Xia LIU ⁷ ; Qi-Zhou LIAN ⁸ ; Xiang XU ⁹ ; Ling-Jing ZUO ¹⁰
Author Information

1. Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China
2. College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China.
3. Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China.
4. Department of Orthopedics, 953 Hospital of PLA, Shigatse Branch of Xinqiao Hospital, Army Medical University, Shigatse, 857000, Tibet Autonomous Region, China.
5. College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China.
6. Department of Rheumatology and Immunology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
7. Department of Obstetrics and Gynecology, Chongqing People's Hospital, Chongqing, 401121, China.
8. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
9. Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China. Electronic address: xiangxu@tmmu.edu.cn.
10. Department of Nuclear Medicine, The First People's Hospital of Yunnan province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650034, China. Electronic address: zlj700105@qq.com.
Publication Type:Journal Article
Keywords: Immunomodulation; MSCs; PD-L1
MeSH: Humans; B7-H1 Antigen/metabolism*; Mesenchymal Stem Cells/immunology*; T-Lymphocytes/metabolism*; Immunomodulation
From: Chinese Journal of Traumatology 2024;27(1):1-10
CountryChina
Language:English
Abstract: Programmed cell death 1 ligand 1 (PD-L1) is an important immunosuppressive molecule, which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1. The PD-L1 expression disorder plays an important role in the occurrence, development, and treatment of sepsis or other inflammatory diseases, and has become an important target for the treatment of these diseases. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells with multiple differentiation potential. In recent years, MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases. Moreover, PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases. In this review, we will summarize the main regulatory mechanism of PD-L1 expression, and discuss various biological functions of PD-L1 in the immune regulation of MSCs.