Research progress on mTOR signaling pathway and regulatory T cell nutrition metabolic regulation mechanism.
- Author:
Ming WU
1
,
2
;
Fang WANG
3
Author Information
1. Department of Laboratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029
2. Department of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
3. Department of Laboratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. *Corresponding author, E-mail: wangfang@njmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Immunosuppression Therapy;
Metabolic Reprogramming;
Signal Transduction;
Sirolimus;
T-Lymphocytes, Regulatory;
TOR Serine-Threonine Kinases;
Humans
- From:
Chinese Journal of Cellular and Molecular Immunology
2024;40(1):69-73
- CountryChina
- Language:Chinese
-
Abstract:
In the tumor microenvironment, metabolic reprogramming can impact metabolic characteristics of T cells, thus inducing immunosuppression to promote tumor immune escape. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in regulating diverse functions of various immune cells. This review mainly focuses on the molecular mechanism of mTOR signaling in regulating cellular energy metabolism process, and the activation status of mTOR signaling under different nutritional environments. In addition, it also summarizes the role of the mTOR signaling in regulatory T cell (Tregs) metabolism and function in current studies, and evaluates the potential of mTOR as a clinical immunotherapeutic target and its current application challenges.
