Expression of CD226 in the small intestinal group 3 innate lymphoid cells (ILC3) in mice.
- Author:
Lu YANG
1
;
Jingchang MA
2
;
Yitian LIU
2
;
Tingting WANG
1
;
Yuling WANG
2
;
Ran ZHUANG
2
;
Zhengxiang ZHANG
3
Author Information
1. Medical College of Yan'an University, Yan'an 716000, China.
2. Department of Immunology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China.
3. Medical College of Yan'an University, Yan'an 716000, China. *Corresponding author, E-mail: zhangzhengxiang168@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Mice;
Colitis/chemically induced*;
Immunity, Innate;
Intestine, Small;
Lymphocytes;
Mice, Inbred C57BL
- From:
Chinese Journal of Cellular and Molecular Immunology
2024;40(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of adhesion molecule CD226 on the small intestinal group 3 innate lymphoid cells (ILC3) in mice. Methods The bioinformatics was used to analyze the expression of CD226 on murine ILCs. Small intestinal mucosal lamina propria lymphocytes (LPL) were isolated from wild-type C57BL/6J mice, and the expression of CD226 on ILC1 and ILC3 was detected by flow cytometry. A mouse model of dextran sulfate sodium (DSS)-induced colitis was constructed to observe the changes in the expression of CD226 on ILC3. Results Both ILC1 and ILC3 in the mice small intestine expressed CD226 molecules; the proportion of ILC3 was reduced, while the expression level of CD226 on ILC3 was increased in the colitis model. Conclusion CD226 is expressed on the small intestines of mice, and although the proportion of ILC3 decreases in the DSS-induced colitis, the expression of CD226 on ILC3 increases.
