Research progress of the effect of "gut-immune" axis on bone homeostasis.
- Author:
Jingyi LIU
1
;
Wantao DONG
2
;
Shiming QIU
1
;
Peng YUAN
1
;
Pan YANG
1
Author Information
1. Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.
2. Department of Sports Medicine, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China. *Corresponding author, E-mail: dwt130@126.com.
- Publication Type:Journal Article
- MeSH:
Gastrointestinal Tract;
Gastrointestinal Microbiome;
Immune System;
Bone Density;
Homeostasis
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(12):1146-1150
- CountryChina
- Language:Chinese
-
Abstract:
Bone homeostasis is based on the dynamic balance of bone formation and bone resorption. An imbalance in bone homeostasis is a major contributor to many skeletal diseases, including osteoporosis. Changes in the composition and diversity of the gut microbiota (GM) are supposed to have a significant impact on bone homeostasis and are closely correlated with changes in bone mass and bone microarchitecture. The "gut-immune" axis, which is formed by the interaction between the host intestinal immune system and GM, is essential for maintaining bone homeostasis, as well as regulating the body's immunological response and maintaining immune homeostasis throughout the intestine and body. The article reviews recent advances in the study of GM, the immune system, and their synergistic impact on bone homeostasis.
