Research progress in immunology of DNA-dependent activator of IFN-regulatory factors (DAI) as a pattern recognition receptor.
- Author:
Pengrui CHENG
1
;
Yi MA
2
Author Information
1. Department of Organ Transplantation, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
2. Department of Organ Transplantation, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China. *Corresponding author, E-mail: anhuimayi2002@163.com.
- Publication Type:Journal Article
- MeSH:
DNA/metabolism*;
Receptors, Pattern Recognition;
Immunity, Innate;
Signal Transduction/genetics*;
DNA-Binding Proteins/genetics*
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(12):1141-1145
- CountryChina
- Language:Chinese
-
Abstract:
DNA sensor, a kind of pattern recognition receptor (PRR), is widely expressed in innate immune cells. It activates the inflammatory signaling pathways and triggers an innate immune response by recognizing the pathogens or DNA in abnormal host cells. DNA-dependent activator of IFN-regulatory factors (DAI) is the first cytoplasmic DNA receptor discovered, which plays an important role in regulating the innate immune responses characterized by induction of interferon and programmed cell death. The article summarizes the molecular characteristics of DAI, its downstream signaling pathways, and its role and mechanism in anti-infective immunity, tumor immunity and inflammatory diseases. It also makes a preliminary exploration of the correlation between DAI and transplantation immunology, and provides a new target for the therapy of various immune diseases.
