Changes in the proportion of lymphocyte subsets and the expression of surface receptors in peripheral blood of patients with colorectal cancer.
- Author:
Yihua HUI
1
;
Haina WANG
2
;
Yani CUI
3
;
Yijun DUAN
2
;
Laifeng REN
2
;
Wen SU
4
Author Information
1. Department of Gastroenterology, Taiyuan Central Hospital, Taiyuan 030009, China.
2. Affiliated Cancer Hospital of Shanxi Medical University Shanxi Cancer Institute, Taiyuan 030013, China.
3. Immunology Department of the Second Clinical College of Shanxi Medical University, Taiyuan 030001, China.
4. Affiliated Cancer Hospital of Shanxi Medical University Shanxi Cancer Institute, Taiyuan 030013, China. *Corresponding author, E-mail: 13509731663@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Lymphocyte Subsets;
Killer Cells, Natural;
Lymphocyte Count;
Receptors, Chemokine;
Colorectal Neoplasms
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(9):828-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the sets of lymphocytes that could systematically evaluate immune function of colorectal cancer patients, based on the expression of colorectal cancer T cells, natural killer (NK) cells, and NKT cell surface protein receptors. Methods Peripheral blood samples from 144 patients with colorectal cancer and 87 healthy controls were collected, and the differences in surface receptors of lymphocyte subsets in peripheral blood of patients and healthy controls were analyzed by means of flow cytometry and cell culture. Results Compared with healthy control group, the percentage of peripheral blood total lymphocytes, CD16brightCD56dimNK cells and NKT cells decreased in patients with colorectal cancer. The percentage of T cells, CD16brightCD56dimNK cells and NKT cell surface inhibitory receptors T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitor motif domains (TIGIT) increased; T cells, NK cells, NKT cell surface chemokine receptor C-C motif chemokine receptor 7 (CCR7) slightly decreased. Conclusion There are differences in the proportion of NK cell subsets and the expression profile of surface receptors in peripheral blood of patients with colorectal cancer.
