Research updates of osteoimmunomodulation in osteogenesis.
- Author:
Yaping MA
1
;
Weiqun WANG
2
;
Dingmei ZHANG
1
;
Jun AO
2
;
Xin WANG
3
Author Information
1. Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Joint Orthopaedic Research Center of Zunyi Medical University & University of Rochester Medical Center (JCMR-ZMU & URMC), Zunyi Medical University, Zunyi 563000, China.
2. Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
3. Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Joint Orthopaedic Research Center of Zunyi Medical University & University of Rochester Medical Center (JCMR-ZMU & URMC), Zunyi Medical University, Zunyi 563000, China.*Corresponding author, E-mail: lchwx@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Osteogenesis;
Cytokines;
Biocompatible Materials;
Macrophages;
T-Lymphocytes;
Bone Regeneration
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(8):759-766
- CountryChina
- Language:Chinese
-
Abstract:
The gold-standard for bone substitution of large bone defects continues to be autogenous bone graft. Artificial bone substitutes are difficult to replace the autogenous bone grafting due to excessive immune response, fast biodegradation characteristics and inappropriate biocompatibility. Given these drawbacks, osteoimmunology and its advanced functional biomaterials have gained growing attention in recent years. Immune system plays an essential role during bone healing via regulating the shift from inflammatory to anti-inflammation phenotype, and inflammatory cytokines response. The inflammatory reaction mainly include infiltration of immune cells (such as macrophages, neutrophils, T cells, B cells, etc) and release of inflammatory factors (such as IL-1β, IL-6, TNF-α, etc.) at the bone defects, which subsequently affect the step-wised process of bone healing rejuvenation. Hence, advanced bone biomaterials with immunomodulatory properties is of great significance for the treatment of patients with recalcitrant bone defects, especially for delayed healing or non-union. The reciprocal mechanism of immuno-modulated bone healing, however, is not fully understood and more research is required in the future.
