Research progress on the role of monocytes in viral hemorrhagic fevers.
- Author:
Hongyan SHI
1
,
2
;
Kang TANG
3
;
Xuyang ZHENG
4
;
Ying ZHANG
5
Author Information
1. Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038
2. Medical College of Yan'an University, Yan'an 716000, China.
3. Department of Immunology, Air Force Medical University, Xi'an 710032, China.
4. Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China. *Corresponding authors, E-mail: zhengxuyang123456@126.com.
5. Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China. *Corresponding authors, E-mail: zyfmmu@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Monocytes;
Endothelial Cells;
Hemorrhagic Fevers, Viral/pathology*;
Immunity;
Cytokines
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(8):748-752
- CountryChina
- Language:Chinese
-
Abstract:
Monocytes are important target cells of various hemorrhagic fever viruses. In viral hemorrhagic fevers (VHFs), monocytes can be infected by viruses and produce different kinds of cytokines, which contribute to the antiviral immune response and participation in the immunopathogenesis of VHFs. During the pathogenesis of various VHFs (early stage), monocytes change in cell counting, subpopulation distribution and expression of surface molecules with an activated phenotype. Several hemorrhagic fever viruses can infect monocytes and induce immune response, which may play an important role in immunopathological injury. Monocytes and the cytokines they produce may interact with platelets and vascular endothelial cells, contributing to disease progression.
