Process of Forensic Medicine in DNA Identification of Aged Human Remains.
10.12116/j.issn.1004-5619.2021.511209
- Author:
Lu CHEN
1
;
Zhe ZHOU
1
;
Sheng-Qi WANG
1
Author Information
1. Bioinformatics Center of Academy of Military Medical Sciences, Beijing 100850, China.
- Publication Type:Journal Article
- Keywords:
aged skeleton;
degraded;
forensic genetics;
high throughput sequencing;
individual identification;
review;
tooth
- MeSH:
Humans;
Aged;
Body Remains;
DNA/analysis*;
Tooth;
DNA Fingerprinting;
Sequence Analysis, DNA
- From:
Journal of Forensic Medicine
2023;39(5):478-486
- CountryChina
- Language:English
-
Abstract:
Skeleton and teeth are important biological samples. Due to their special structure and strong ability to resist degradation, they are ideal biological materials to retain DNA under natural condition. In many cases, such as historical figure identification, aged skeleton and teeth are usually the only biological samples. However, their DNA is in a state of trace, damage and degradation to different degrees, which requires special experimental treatment to achieve identification. This paper reviews the sample selection, DNA extraction, DNA enrichment and analysis approaches based on relevant research reports in recent years, aiming to promote the further development and improvement of the aged skeleton and teeth identification system.
