Influence of thyroid function on the fetal fraction during second trimester of pregnancy.
10.3760/cma.j.cn511374-20220606-00389
- VernacularTitle:孕中期甲状腺功能对胎儿游离DNA分数的影响
- Author:
Yuqiong ZHANG
1
,
2
;
Longwei QIAO
;
Ting WANG
Author Information
1. Department of Medical Laboratory, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu 215002, China. 273035701@qq.com
2. biowt@njmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Pregnancy;
Female;
Humans;
Pregnancy Trimester, Second;
Thyroid Gland;
Thyroxine;
Fetus;
Gestational Age
- From:
Chinese Journal of Medical Genetics
2023;40(10):1191-1196
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the influence of thyroid function on the fetal fraction (FF) during the second trimester of pregnancy.
METHODS:A total of 1 861 pregnant women undergoing non-invasive prenatal testing (NIPT) and thyroxine function testing at 12 ~ 26 gestational weeks at the Affiliated Suzhou Hospital of Nanjing Medical University/Suzhou Municipal Hospital from January 2016 to December 2020 were selected as the study subjects. Univariate analysis and multivariate regression models were used to assess the correlation between free thyroxine 4 (FT4) levels and FF.
RESULTS:Univariate linear regression analysis indicated that the FF is correlated to the level of FT4 (b = 0.035, P < 0.001). The median fetal FF was 10.78% (IQR: 8.2%, 13.82%), and this has increased along with the level of FT4 from 10.58% at <= 12.0 pmol/L to 11.77% at > 16.0 pmol/L. After further adjustment of gestational age and body mass index (BMI), the FF showed an increase trend along with the increase of FT4 levels, and a trend test also showed a statistical significance (Ptrend < 0.001).
CONCLUSION:Maternal FF can be affected by the level of free thyroxine during the second trimester of pregnancy.
