Diagnosis and treatment of a child with alveolar capillary dysplasia with misalignment of pulmonary veins due to variant of FOXF1 gene.
10.3760/cma.j.cn511374-20220511-00320
- VernacularTitle:FOXF1基因变异致肺泡毛细血管发育不良并肺静脉错位患儿1例的诊治及基因分析
- Author:
Weifeng ZHANG
1
;
Zhiyong LIU
;
Weiru LIN
;
Fengfeng ZHANG
;
Jinglin XU
;
Xiaoqing LI
;
Ruiquan WANG
;
Lianqiang WU
;
Dongmei CHEN
Author Information
1. Graduate School, Fujian Medical University, Fuzhou, Fujian 350000, China. chengdm9090@163.com.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Child;
Infant, Newborn;
Pregnancy;
Persistent Fetal Circulation Syndrome/therapy*;
Hypertension, Pulmonary;
Pulmonary Veins;
Forkhead Transcription Factors/genetics*
- From:
Chinese Journal of Medical Genetics
2023;40(9):1171-1175
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the diagnosis, treatment and genetic characteristics of a neonate with severe pulmonary hypertension and respiratory failure.
METHODS:Perinatal history, clinical manifestations, laboratory finding and diagnosis and treatment data of the child were collected. Whole exome sequencing was carried out for the child, and Sanger sequencing was used to verify the candidate variants.
RESULTS:The female neonate has developed progressive respiratory failure and refractory pulmonary hypertension shortly after birth. Conventional treatment such as mechanical ventilation, vasoactive drugs, and inhaled nitric oxide were ineffective. She has developed sustained pulmonary hypertension after weaning from extracorporeal membrane oxygenation therapy, and had died after the treatment had ceased. Whole exome sequencing revealed that she has harbored a heterozygous de novo variant of c.682_683insGCGGCGGC (p.G234Rfs*148) of the FOXF1 gene, which was predicted as pathogenic based on guidelines from the American College of Medical Genetics and Genomics (ACMG), with evidence items of PVS1_Strong+PM2_Supporting+PS2. Based on her clinical manifestations and result of genetic testing, the child was diagnosed with alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD/MPV).
CONCLUSION:Discovery of the c.682_683insGCGGCGGC (p.G234 Rfs*148) variant of the FOXF1 gene has expanded the mutational spectrum of the FOXF1 gene, which has facilitated implementation of specific treatment and provided a basis for clinical diagnosis and genetic counseling.
