Regulation of non-coding RNA in type H vessels angiogenesis of bone.
10.7507/1002-1892.202304032
- Author:
Shengping TANG
1
;
Shijie LIAO
1
;
Jianhong LIU
1
;
Xiaolin LUO
1
;
Zhendi WEI
1
;
Xiaofei DING
1
Author Information
1. Department of Trauma Orthopedic and Hand Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021, P. R. China.
- Publication Type:Journal Article
- Keywords:
Non-coding RNA;
angiogenesis;
osteogenesis;
regulation;
type H vessels
- MeSH:
Humans;
RNA, Untranslated/genetics*;
RNA, Long Noncoding;
Bone Diseases/genetics*;
MicroRNAs/genetics*;
RNA, Small Interfering
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2023;37(8):1042-1048
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To summarize the regulatory effect of non-coding RNA (ncRNA) on type H vessels angiogenesis of bone.
METHODS:Recent domestic and foreign related literature about the regulation of ncRNA in type H vessels angiogenesis was widely reviewed and summarized.
RESULTS:Type H vessels is a special subtype of bone vessels with the ability to couple bone formation. At present, the research on ncRNA regulating type H vessels angiogenesis in bone diseases mainly focuses on microRNA, long ncRNA, and small interfering RNA, which can affect the expressions of hypoxia inducible factor 1α, platelet derived growth factor BB, slit guidance ligand 3, and other factors through their own unique ways of action, thus regulating type H vessels angiogenesis and participating in the occurrence and development of bone diseases.
CONCLUSION:At present, the mechanism of ncRNA regulating bone type H vessels angiogenesis has been preliminarily explored. With the deepening of research, ncRNA is expected to be a new target for the diagnosis and treatment of vascular related bone diseases.
