Research progress on the influence of Modic changes on lumbar interbody fusion and its treatment measure.
10.7507/1002-1892.202302007
- Author:
Yang XIAO
1
;
Xi YANG
1
Author Information
1. Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
- Publication Type:Journal Article
- Keywords:
Lumbar;
Modic changes;
lumbar interbody fusion;
treatment measure
- MeSH:
Humans;
Lumbosacral Region/surgery*;
Osteoporosis;
Spinal Fusion;
Treatment Failure
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2023;37(8):1026-1030
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review the research progress of Modic changes and its influence on lumbar interbody fusion.
METHODS:The domestic and foreign literature related to Modic changes and its influence on lumbar interbody fusion was extensively reviewed. The etiology of Modic changes was summarized, and the treatment measures of Modic changes on lumbar interbody fusion were discussed.
RESULTS:The etiology of Modic changes is not clear, which may be related to mechanical factors, autoimmune factors, low toxic infection factors, and genetic factors. Modic changes may lead to fusion failure and cage subsidence after lumbar interbody fusion. Preoperative evaluation of endplate sclerosis, reduction of iatrogenic endplate injury, fine operating of intervertebral space, management of osteoporosis, and selection of appropriate cage can prevent or reduce fusion failure or cage subsidence.
CONCLUSION:Modic changes may lead to fusion failure and cage subsidence after lumbar interbody fusion, and active perioperative intervention of Modic changes is helpful to improve the clinical prognosis.
