Near-infrared excited graphene oxide/silver nitrate/chitosan coating for improving antibacterial properties of titanium implants.
10.7507/1002-1892.202303041
- Author:
Yifan WANG
1
;
Yingde XU
1
;
Xuefeng ZHANG
1
;
Jingyu LIU
1
;
Jintong HAN
1
;
Shengli ZHU
1
;
Yanqin LIANG
1
;
Shuilin WU
1
;
Zhenduo CUI
1
;
Weijia LÜ
2
;
Zhaoyang LI
1
Author Information
1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, P. R. China.
2. Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences, Shenzhen Guangdong, 518055, P. R. China.
- Publication Type:Journal Article
- Keywords:
Bacterial infection;
antibacterial coating;
heterojunction;
photothermal-photodynamic antibacterial
- MeSH:
Chitosan;
Silver Nitrate;
Titanium;
Anti-Bacterial Agents/pharmacology*;
Coloring Agents
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2023;37(8):937-944
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To design and construct a graphene oxide (GO)/silver nitrate (Ag3PO4)/chitosan (CS) composite coating for rapidly killing bacteria and preventing postoperative infection in implant surgery.
METHODS:GO/Ag3PO4 composites were prepared by ion exchange method, and CS and GO/Ag3PO4 composites were deposited on medical titanium (Ti) sheets successively. The morphology, physical image, photothermal and photocatalytic ability, antibacterial ability, and adhesion to the matrix of the materials were characterized.
RESULTS:The GO/Ag3PO4 composites were successfully prepared by ion exchange method and the heterogeneous structure of GO/Ag3PO4 was proved by morphology phase test. The heterogeneous structure formed by Ag3PO4 and GO reduced the band gap from 1.79 eV to 1.39 eV which could be excited by 808 nm near-infrared light. The photothermal and photocatalytic experiments proved that the GO/Ag3PO4/CS coating had excellent photothermal and photodynamic properties. In vitro antibacterial experiments showed that the antibacterial rate of the GO/Ag3PO4/CS composite coating against Staphylococcus aureus reached 99.81% after 20 minutes irradiation with 808 nm near-infrared light. At the same time, the composite coating had excellent light stability, which could provide stable and sustained antibacterial effect.
CONCLUSION:GO/Ag3PO4/CS coating can be excited by 808 nm near infrared light to produce reactive oxygen species, which has excellent antibacterial activity under light.
