Research progress of chondrocyte mechanotransduction mediated by TRPV4 and PIEZOs.
10.7507/1001-5515.202301029
- Author:
Qiang ZHANG
1
;
K Tawiah GODFRED
1
;
Yanjun ZHANG
1
;
Xiaochun WEI
2
;
Weiyi CHEN
1
;
Quanyou ZHANG
1
Author Information
1. College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.
2. Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, the Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, P. R. China.
- Publication Type:Journal Article
- Keywords:
Calcium signaling;
Chondrocyte;
Matrix microenvironment;
Osteoarthritis;
PIEZOs;
TRPV4
- MeSH:
Chondrocytes;
TRPV Cation Channels;
Mechanotransduction, Cellular;
Biocompatible Materials;
Cartilage, Articular
- From:
Journal of Biomedical Engineering
2023;40(4):638-644
- CountryChina
- Language:Chinese
-
Abstract:
Mechanical signal transduction are crucial for chondrocyte in response to mechanical cues during the growth, development and osteoarthritis (OA) of articular cartilage. Extracellular matrix (ECM) turnover regulates the matrix mechanical microenvironment of chondrocytes. Thus, understanding the mechanotransduction mechanisms during chondrocyte sensing the matrix mechanical microenvironment can develop effective targeted therapy for OA. In recent decades, growing evidences are rapidly advancing our understanding of the mechanical force-dependent cartilage remodeling and injury responses mediated by TRPV4 and PIEZOs. In this review, we highlighted the mechanosensing mechanism mediated by TRPV4 and PIEZOs during chondrocytes sensing mechanical microenvironment of the ECM. Additionally, the latest progress in the regulation of OA by inflammatory signals mediated by TRPV4 and PIEZOs was also introduced. These recent insights provide the potential mechanotheraputic strategies to target these channels and prevent cartilage degeneration associated with OA. This review will shed light on the pathogenesis of articular cartilage, searching clinical targeted therapies, and designing cell-induced biomaterials.
