Biomechanical properties of epithelial mesenchymal transition in idiopathic pulmonary fibrosis.
10.7507/1001-5515.202206016
- Author:
Mingyan LI
1
;
Meihao SUN
1
;
Yuanbo JIA
2
;
Hui REN
2
;
Han LIU
1
Author Information
1. Henan University of Chinese Medicine, Academy of Chinese Medicine Sciences, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan & Ministry of Education of PR China, Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450016, P.R. China.
2. Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Xi'an 710049, P.R. China.
- Publication Type:Journal Article
- Keywords:
Biomechanical microenvironment;
Biomechanical receptors;
Matrix stiffness;
Mechanical stretch;
Pulmonary fibrosis
- MeSH:
Humans;
Epithelial-Mesenchymal Transition;
Idiopathic Pulmonary Fibrosis;
Signal Transduction
- From:
Journal of Biomedical Engineering
2023;40(4):632-637
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a progressive scar-forming disease with a high mortality rate that has received widespread attention. Epithelial mesenchymal transition (EMT) is an important part of the pulmonary fibrosis process, and changes in the biomechanical properties of lung tissue have an important impact on it. In this paper, we summarize the changes in the biomechanical microenvironment of lung tissue in IPF-EMT in recent years, and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonary fibrosis on the process of EMT, the effects of mechanical factors on the behavior of alveolar epithelial cells in EMT and the biomechanical signaling in EMT, in order to provide new references for the research on the prevention and treatment of IPF.
