Research progress on vascularization of organoids.
10.7507/1001-5515.202211011
- Author:
Junyi SHEN
1
;
Zhi OUYANG
1
;
Jian ZHONG
1
;
Yicen LONG
1
;
Yujia SUN
1
;
Ye ZENG
1
Author Information
1. Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China.
- Publication Type:Journal Article
- Keywords:
Blood vessels;
Coculture;
Endothelial cells;
Organoids;
Stem cells
- MeSH:
Humans;
Organoids;
Neovascularization, Pathologic;
Technology
- From:
Journal of Biomedical Engineering
2023;40(4):625-631
- CountryChina
- Language:Chinese
-
Abstract:
Organoids are three-dimensional structures formed by self-organizing growth of cells in vitro, which own many structures and functions similar with those of corresponding in vivo organs. Although the organoid culture technologies are rapidly developed and the original cells are abundant, the organoid cultured by current technologies are rather different with the real organs, which limits their application. The major challenges of organoid cultures are the immature tissue structure and restricted growth, both of which are caused by poor functional vasculature. Therefore, how to develop the vascularization of organoids has become an urgent problem. We presently reviewed the progresses on the original cells of organoids and the current methods to develop organoids vascularization, which provide clues to solve the above-mentioned problems.
