Chemical constituents from Salacia polysperma.
10.19540/j.cnki.cjcmm.20230810.202
- Author:
Xin-Yu YAN
1
;
Die XIAO
1
;
Qi NIU
1
;
Hao-Nan XU
1
;
Hao-Xin WANG
1
;
Hong-Ping HE
1
;
Zhi-Yong JIANG
1
Author Information
1. Key Laboratory of Modern Research on Ethnic Medicine in Yunnan Provincial Universities, Ethnomedicine School,Yunnan University of Chinese Medicine Kunming 650500, China.
- Publication Type:Journal Article
- Keywords:
Salacia;
Salacia polysperma;
chemical constituents;
α-glucosidase inhibitory activity
- MeSH:
Salacia/chemistry*;
alpha-Glucosidases;
Triterpenes/pharmacology*;
Magnetic Resonance Spectroscopy;
Ethanol;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2023;48(24):6676-6681
- CountryChina
- Language:Chinese
-
Abstract:
Nine compounds were isolated from the 90% ethanol extract of Salacia polysperma by silica gel, Sephadex LH-20 column chromatography, together with preparative HPLC methods. Based on HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, the structures of the nine compounds were identified as 28-hydroxy wilforlide B(1), wilforlide A(2), 1β,3β-dihydroxyurs-9(11),12-diene(3),(-)-epicatechin(4),(+)-catechin(5),(-)-4'-O-methyl-ent-galloepicatechin(6), 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one(7),(-)-(7S,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7,9-diol-7'-aldehyde(8), and vanillic acid(9). Compound 1 is a new oleanane-type triterpene lactone. Compounds 1, 3, 4, 7-9 were isolated from the Salacia genus for the first time. All compounds were assayed for their α-glucosidase inhibitory activity. The results suggested that compound 8 exhibited moderate α-glucosidase inhibitory activity, with an IC_(50) value of 37.2 μmol·L~(-1), and the other compounds showed no α-glucosidase inhibitory activity.
