Advances in mechanism of traditional Chinese medicine in inhibiting angiogenesis in ovarian cancer.
10.19540/j.cnki.cjcmm.20230712.704
- Author:
Mao-Yan TANG
1
;
Dan-Ni DING
1
;
Ya-Ya XIE
1
;
Fang SHEN
1
;
Jia LI
2
;
Fang-Yuan LIU
2
;
Feng-Juan HAN
2
Author Information
1. Heilongjiang University of Traditional Chinese Medicine Harbin 150040,China.
2. the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Harbin 150040, China.
- Publication Type:Journal Article
- Keywords:
VEGF;
angiogenesis;
mechanism of action;
ovarian cancer;
traditional Chinese medicine
- MeSH:
Humans;
Female;
Medicine, Chinese Traditional;
Vascular Endothelial Growth Factor A/metabolism*;
Endothelial Cells/metabolism*;
Angiogenesis;
Angiogenesis Inhibitors/therapeutic use*;
Ovarian Neoplasms/genetics*;
Neovascularization, Pathologic/genetics*
- From:
China Journal of Chinese Materia Medica
2023;48(24):6572-6581
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer is one of the three major cancers in gynecology. Ovarian cancer has insidious symptoms in its early stages and mostly has progressed to advanced stages when detected. Surgical treatment combined with chemotherapy is currently the main treatment, but the 5-year survival rate is still less than 45%. Angiogenesis is a key step in the growth and metastasis of ovarian cancer. The inhibition of ovarian cancer angiogenesis has become a new hotspot in anti-tumor targeted therapy, which has many advantages such as less drug resistance, high specificity, few side effects, and broad anti-tumor spectrum. Modern research has confirmed that traditional Chinese medicine(TCM) can inhibit tumor angiogenesis by inhibiting the expression of pro-angiogenic factors, up-regulating the expression of anti-angiogenic factors, inhibiting the proliferation of vascular endothelial cells, reducing the density of tumor microvessels, and regulating related signaling pathways, with unique advantages in the treatment of ovarian cancer. This paper presented a review of the role of TCM in inhibiting ovarian cancer angiogenesis in order to provide references for the optimization of clinical ovarian cancer treatment strategies.
