Comparison of active components in different parts of Perilla frutescens and its pharmacological effects.
10.19540/j.cnki.cjcmm.20230813.201
- Author:
Liang-Qi ZHANG
1
;
Wen-Jiao LI
1
;
Mei-Feng XIAO
1
Author Information
1. College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine Changsha 410208, China.
- Publication Type:Journal Article
- Keywords:
Perilla frutescens;
active component;
mechanism of action;
pharmacological action;
research advances
- MeSH:
Perilla frutescens/chemistry*;
Plant Extracts/pharmacology*;
Seeds/chemistry*;
Fruit/chemistry*;
Oils, Volatile/analysis*;
Plant Leaves/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(24):6551-6571
- CountryChina
- Language:Chinese
-
Abstract:
Perilla frutescens is a widely used medicinal and edible plant with a rich chemical composition throughout its whole plant. The Chinese Pharmacopoeia categorizes P. frutescens leaves(Perillae Folium), seeds(Perillae Fructus), and stems(Perillae Caulis) as three distinct medicinal parts due to the differences in types and content of active components. Over 350 different bioactive compounds have been reported so far, including volatile oils, flavonoids, phenolic acids, triterpenes, sterols, and fatty acids. Due to the complexity of its chemical composition, P. frutescens exhibits diverse pharmacological effects, including antibacterial, anti-inflammatory, anti-allergic, antidepressant, and antitumor activities. While scholars have conducted a substantial amount of research on different parts of P. frutescens, including analysis of their chemical components and pharmacological mechanisms of action, there has yet to be a systematic comparison and summary of chemical components, pharmacological effects, and mechanisms of action. Therefore, this study overviewed the chemical composition and structures of Perillae Folium, Perillae Fructus, and Perillae Caulis, and summarized the pharmacological effects and mechanisms of P. frutescens to provide a reference for better development and utilization of this valuable plant.
