Research progress in epigenetic pharmacological effects of rhein.
10.19540/j.cnki.cjcmm.20230927.602
- Author:
Zi-Wei ZHU
1
;
Ruo-Nan ZHOU
1
;
Wen-Bin SHANG
2
Author Information
1. Key Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. Key Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine Nanjing 210023, China Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.
- Publication Type:Journal Article
- Keywords:
acetylation;
epigenetics;
methylation;
rhein
- MeSH:
Humans;
Anthraquinones/pharmacology*;
DNA Methylation;
Epigenesis, Genetic;
Neoplasms/drug therapy*;
Fibrosis
- From:
China Journal of Chinese Materia Medica
2023;48(24):6545-6550
- CountryChina
- Language:Chinese
-
Abstract:
Rhein, which is one of the main active components of Rheum palmatum, has a range of pharmacological activities such as the regulation of the metabolism of glucose and lipids, anti-inflammatory, anti-tumor, anti-fibrosis, etc. Epigenetics refers to the heritable variation of gene expression without altering the DNA sequence. It is involved in the emergence and development of inflammation, renal fibrosis, diabetes, cancer, atherosclerosis, and other diseases, thus becoming a new strategy for the treatment of many di-seases. A series of studies have shown that epigenetic modification may be a common molecular mechanism of various pharmacological effects of rhein. This paper summarized the effects of rhein on the regulation of epigenetic modification and its underlying mechanisms, which involve the regulation of DNA methylation, protein acetylation, and RNA methylation, so as to provide a basis for the development and application of rhein.
