Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum.
10.19540/j.cnki.cjcmm.20230618.203
- Author:
De-Li CHEN
1
;
Guo-Xu MA
2
;
Hui-Mei LIU
1
;
Can-Hong WANG
1
;
Yang-Yang LIU
1
;
Yun YANG
1
;
Jian-He WEI
2
Author Information
1. Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Haikou 570311, China.
2. Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Haikou 570311, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
- Publication Type:Journal Article
- Keywords:
Qi-nan Aquilariae Lignum Resinatum;
elemane-type sesquiterpene;
eudesmane-type sesquiterpene;
neuroprotection
- MeSH:
Rats;
Animals;
Qi;
Sesquiterpenes/pharmacology*;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2023;48(23):6403-6407
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.
