Research progress in pharmacological effectsand mechanism of Fel Ursi against cardiovascular and cerebrovascular diseases.
10.19540/j.cnki.cjcmm.20230823.601
- Author:
Li-Dan ZHU
1
;
Jie LIAO
1
;
Xiao-Yan LU
2
;
Xiao-Hui FAN
1
Author Information
1. Polytechnic Institute, Zhejiang University Hangzhou 310015, China Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University Jiaxing 314103, China.
2. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University Jiaxing 314103, China.
- Publication Type:Journal Article
- Keywords:
Fel Ursi;
anti-apoptosis;
anti-inflammation;
anti-oxidative stress;
coronary heart disease;
stroke
- MeSH:
Animals;
Cerebrovascular Disorders/drug therapy*;
Bile Acids and Salts;
Lung;
Liver;
Ursidae;
Cardiovascular Diseases/drug therapy*
- From:
China Journal of Chinese Materia Medica
2023;48(23):6307-6314
- CountryChina
- Language:Chinese
-
Abstract:
Fel Ursi is a dried product obtained from the gallbladder of Ursidae animals, such as Selenarctos thibetanus or Ursus arctos, through gallbladder surgery for bile drainage. It is one of the rare animal medicinal materials in China and is known for its therapeutic effects, including clearing heat, removing toxins, extinguishing wind, relieving spasms, clearing the liver, and improving vision. Research has also found that Fel Ursi has pharmacological effects against cardiovascular and cerebrovascular diseases, such as anti-inflammatory, anti-apoptotic, and antioxidant stress properties. Recently, numerous studies have confirmed the close relationship between cardiovascular and cerebrovascular diseases and the gut microbiota as well as gut metabolites. Fel Ursi contains bile acid components that may have bidirectional regulatory effects on the gut microbiota and gut metabolites. This aspect could represent a potential therapeutic pathway for Fel Ursi in the treatment of cardiovascular and cerebrovascular diseases. This article comprehensively summarized relevant literature in China and abroad, reviewed the research progress on the pharmacological effects of Fel Ursi against cardiovascular and cerebrovascular diseases, and explored the impact of Fel Ursi on gut microbiota and gut metabolites, thereby aiming to provide references for further in-depth research and clinical application of Fel Ursi.
