Chemical constituents from whole herb of Hedyotis scandens.
10.19540/j.cnki.cjcmm.20230616.203
- Author:
Yu-Jun WANG
1
;
Ju-Min HUANG
1
;
Chun WEN
1
;
Zi-Shuo ZHOU
1
;
Qiao-Qiao FENG
1
;
Chang-Hua HU
1
;
Pei-Fu ZHOU
2
;
Guo-Ping YIN
1
Author Information
1. Engineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China.
2. Key Laboratory of Guizhou Ethnic Medicine Resource Development and Utilization in Guizhou Minzu University, State Ethnic Affairs Commission, School of Ethnic-Minority Medicine,Guizhou Minzu University Guiyang 550025, China.
- Publication Type:Journal Article
- Keywords:
Hedyotis genus;
antibacterial activity;
chemical constituent;
whole herb of Hedyotis scandens
- MeSH:
Hedyotis/chemistry*;
Drugs, Chinese Herbal/chemistry*;
Magnetic Resonance Spectroscopy;
Salicylic Acid
- From:
China Journal of Chinese Materia Medica
2023;48(22):6082-6087
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to investigate the chemical constituents in the water extract of the whole herb of Hedyotis scandens by silica gel, ODS, and MCI column chromatographies together with preparative high-performance liquid chromatography(HPLC). The structures of isolated constituents were identified by NMR, HR-ESI-MS, etc. Thirteen compounds were isolated and identified as methyl 4-benzoyloxy-3-methoxybenzeneacetate(1), 4-benzoyloxy-3-methoxybenzeneacetic acid(2), 3-(4-hydroxy-3-methoxyphenyl)-propanoic acid(3), salicylic acid(4), 3-hydroxy-4-methoxypyridine(5), syringic acid(6), hydroxycinnamic acid(7),(R)-6-methyl-4,6-bis(4-methylpent-3-enyl)cyclohexa-1,3-dienecarbaldehyde(8), 1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol(9), 1H-indole-3-carboxaldehyde(10), isoscopoletin(11), syringaresinol(12), and pinoresinol(13). Among them, compounds 1 and 2 were new phenolic acid compounds, compounds 3-5, 8-11, and 13 were isolated from this genus for the first time, and compounds 6, 7, and 12 were obtained from H. scandens for the first time. The activity test showed that compounds 1 and 10 had a certain inhibitory effect on Mycobacterium smegmatis, with MIC_(50) values of 58.5 and 33.3 μg·mL~(-1), respectively.
